To date, a smart base isolation system has been developed in high seismicity region such as Japan, USA etc. Smart base isolation systems developed for structures in high seismicity region cannot directly applied to structures in regions of low-to-moderate seismicity such as Korea. Therefore, problems that occur by applying the smart base isolation system developed for the structures in high seismicity region to the structures in regions of low-to-moderate seismicity have been investigated in this study. To this end, a spacial arch structure was used as an example structure and MR dampers and low damping elastomeric bearings were used to compose a smart base isolation system. Artificial earthquakes were used for ground motions in regions of high and low-to-moderate seismicity. Based on numerical simulation results, it has been known that the capacity of smart base isolation system for the regions of low-to-moderate seismicity should be carefully designed because the base isolation effects of the smart base isolation system for high seismicity region is deteriorated when it is applied to the structures in regions of low-to-moderate seismicity.