The control performance in active structural control system can be drastically deteriorated when the modeling errors and the uncertainties existing in the disturbances are disregarded in the designing stage. It can even throw the control system into an unstable phase, resulting in out of control against the seismic excitations. The purpose of the study is to investigate the control effectiveness of a non-linear control system called sliding mode controller(SMC) in cooperation with a Tuned Mass Damper subjected to the three seismic excitations selected from the FFT analysis. Even though the transient performance such as settling time and overshoot were deteriorated, the robustness against the system stability was appeared from SMC when the structural masses and stiffness perturbed within the range of ${pm}30%$. SMC is a feasible technique for active structural control in cooperation with TMD against seismic disturbances, exhibiting robustness in perturbation of system stiffness and mass as well as uncertainties of the disturbances.