- 중국산 약용식물의 최종당화산물 생성저해활성 검색 (V)
- ㆍ 저자명
- 김영숙,최성훈,김주환,김진숙,Kim. Young-Sook,Choi. Sung-Hoon,Kim. Joo-Hwan,Kim. Jin-Sook
- ㆍ 간행물명
- 생약학회지
- ㆍ 권/호정보
- 2011년|42권 1호|pp.46-53 (8 pages)
- ㆍ 발행정보
- 한국생약학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 66 herbal medicines from China have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 31 herbal medicines ($IC_{50}$ < $50;{mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, 5 herbal medicines, Camptotheca acuminata (branches and leaves), Quercus franchetii (branches), Camellia pitardii (leaves, branches, and fruits), Antidesma bunius (whole plants), and Loranthus parasiticus (whole plants) showed more potent inhibitory activity (approximately 6-20 fold) than the positive control aminoguanidine ($IC_{50}=52.96;{mu}g/ml$).