Safflower is a world-wide plant for multiple uses. flower of safflower is honghwa(紅花) which has been used for heart disease in oriental medicine. but its seed was not used in oriental medicine. after the publication of "Shinyak(神藥)" - the late 1980s, its seed(紅花子, hongwhassi) was known as good for bone fracture, osteoporosis and menopausal disorders. so many researchers studied hongwhassi and delivered lots of papers. the concern of each paper is different. this paper is a review paper. this paper studied documentary records about hongwhassi, and analyzed hongwhassi research trend. the trend consists of cultivation, ingredient analysis, osteoporosis, atherosclerosis, periodontal ligament and phytoestrogen. many papers lack of information about plant origin. so this paper supplements the standard form of plant origin(when sowing, where grow up, which direction, what kind etc).