Purpose: This study was done to identify factors predicting sick-role behavioral compliance in hemodialysis patients. Methods: The subjects were 133 patients from outpatient dialysis clinics at seven major general hospitals located in D and P cities. Data were collected by self-report questionnaires. For data analysis, SPSS/WIN 14.0 program was utilized including one-way ANOVA, independent t-test, Pearson correlation coefficients, and stepwise multiple regression. Results: This study showed a positive correlation between sick-role behavioral compliance and social support (r=.29 p<.001), knowledge (r=.31 p<.001), self-efficacy (r=.52, p<.001) and age (r=.21, p=.015). The factors predicting sick-role behavioral compliance were self-efficacy (${eta}$=.46), knowledge (${eta}$=.25), and age (${eta}$=.18). These factors accounted for 36% of the variance of sick-role behavioral compliance in hemodialysis patients. Conclusion: The results indicate that it is necessary to increase self-efficacy and knowledge in order to improve sick-role behavioral compliance in hemodialysis patients.