Highly Convenient and Large Scale Synthesis of 5-chloroindole and its 3-substituted Analogues

Highly Convenient and Large Scale Synthesis of 5-chloroindole and its 3-substituted Analogues
Highly Convenient and Large Scale Synthesis of 5-chloroindole and its 3-substituted Analogues

ㆍ 저자명: Keetha. Laxminarayana,Palle. Sadanandam,Ramanatham. Vinodkumar,Khagga. Mukkanti,Chinnapillai. Rajendiran
ㆍ 간행물명: 대한화학회지
ㆍ 권/호정보: 2011년|55권 2호|pp.240-242 (3 pages)
ㆍ 발행정보: 대한화학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.

서지반출

영문초록

CuCl과 N-methyl-2-pyrrolidone을 이용하여 5-bromoindole을 halogen - halogen 교환반응을 통하여 5-chloroindole계 화합물을 합성하는 one-pot대량합성방법을 개발하였다.

기타언어초록

A large scale and commercially feasible synthesis of 5-chloroindole and its 3-substituted analogues has been described via a halogen - halogen exchange reaction from 5-bromoindole and its derivatives using cuprous chloride and dipolar aprotic solvent N-methyl-2-pyrrolidone in one pot with good yields.

키워드

염화 구리 (I)N-methyl-2-pyrrolidone halogen-halogen 교환반응 5-haloindoles copper (I) chloride N-methyl-2-pyrrolidone halogen-halogen exchange

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