The inverse problem about the theoretical analysis of a drill string bending in a channel of an inclined bore-hole with localized geometrical imperfections is studied. The system of ordinary differential equations is first derived based on the theory of curvilinear flexible elastic rods. One can then use these equations to investigate the quasi-static effects of the drill string bending that may occur in the process of raising, lowering and rotation of the string inside the bore-hole. The method for numerical solution of the constructed equations is described. With the proposed method, the phenomenon of the drill column movement, its contact interaction with the bore-hole surface, and the frictional seizure can be simulated for different combinations of velocities, directions of rotation and axial motion of the string. Geometrical imperfections in the shape of localized smoothed breaks of the bore-hole axis line are considered. Some numerical examples are presented to illustrate the applicability of the method proposed.