A global-local finite element modeling technique is employed in this paper to predict the fatigue life of radial truck tires. This paper assumes that a flaw exists inside the tire, in the local model. The local model uses an FEM fracture analysis in conjunction with a global-local technique in ABAQUS. A 3D finite element local model calculates the energy release rate at the belt edge. Using the analysis of the local model, a study of the energy release rate is performed in the crack region and used to determine the crack growth rate analysis. The result considers how different driving conditions contribute to the detrimental effects of belt separation in truck tire failure. The calculation of the total mileage on four sizes of radial truck tires has performed on the belt edge separation. The effect of the change of belt width design on the fatigue lifetime of tire belt separation is discussed.