This paper presents the results of an investigation on shear strengthening of RC beams externally reinforced with CFRP composite. A total of six full-scale beams of four CFRP strengthened and two unstrengthened were tested in the absence of internal stirrups in the shear span. The strengthening configurations contained two styles: discrete uniformly spaced strips and customized wide strips over B-regions. The composite systems provided an increase in ultimate strength as compared to the unstrengthened beams. Among the three layouts that had the same area of CFRP, the highest contribution was provided by the customized layout that targeted the B-regions. A comparative study of the experimental results with published empirical equations was conducted in order to evaluate the assumed effective strains. The empirical equations were found to be unconservative. Nonlinear finite element (NLFE) models were developed for the beams. The models agreed with test results that targeting the B-region was more effective than distributing the same CFRP area in a discrete strip style over shear spans. Moreover, the numerical models predicted the contribution of different configurations better than the empirical equations.