Base isolation, having quite simple contents, aims to protect the buildings from earthquake-induced damages by installing structural components having low horizontal stiffness between substructure and superstructure. In this study, an appropriate base isolation system for 2-D reinforced concrete frame is investigated. For different structural heights, the structural systems of 2, 3 and 4 bays are modeled by applying base isolation systems and results are compared with conventional structural systems. 1999 Marmara earthquake data is used for applying the model by time history method in SAP2000 package. Results of various parameters such as base shear force, structure drift ratio, structure period and superstructure acceleration are discussed for all models.