This paper evaluates the effects of topographical and geotechnical irregularities on the dynamic response of the 2-D soil-structure systems under ground motion by coupling finite and infinite elements. A numerical procedure is employed, and a parametric study is carried out for single-faced slope topographies. It is concluded that topographic conditions may have important effects on the ground motion along the slope. The geotechnical properties of the soil will also have significantly amplified effects on the whole system motion, which cannot be neglected for design purposes. So, dynamic response of a soil-structure systems are primarily affected by surface shapes and geotechnical properties of the soil. Location of the structure is another parameter affecting the whole system response.