The cable system is generally considered to be a structural solution to increase the spanning capacity of suspension bridges. In this work, based on the Runyang Bridge over the Yangtze River, three case suspension bridges with different 3D cable systems are designed, structural dynamic characteristics, the aerostatic and aerodynamic stability are investigated numerically by 3D nonlinear aerostatic and aerodynamic analysis, and the cable system favorable to improve the wind-induced instability of long-span suspension bridges is also proposed. The results show that as compared to the example bridge with parallel cable system, the suspension bridge with inward-inclined cable system has greater lateral bending and tensional frequencies, and also better aerodynamic stability; as for the suspension bridge with outward-inclined cable system, it has less lateral bending and tensional frequencies, and but better aerostatic stability; however the suspension bridge is more prone to aerodynamic instability, and therefore considering the whole wind-induced instability, the parallel and inward-inclined cable systems are both favorable for long-span suspension bridges.