In this paper, the seismic response of elevated broad and slender liquid storage tanks isolated by elastomeric or sliding bearings was investigated. The accuracy of predictions of SAP2000 vs. 3D-BASIS-ME programs was examined. A comparative study of the performance of base isolated tanks when isolation bearings are placed at the top or at the bottom of the supporting tower structure was conducted. It was found that base isolation is quite effective in reducing the earthquake response of elevated liquid storage tanks in which high reductions of base shear and shaft displacement were achieved. Modeling the isolated tanks in SAP2000 was very successful in producing results that are nearly identical to those of program 3D-BASIS-ME. Placing the isolators at the top of the shaft in elevated tanks proved to be much better than placing them at the bottom.