Purpose: This study is designed to examine the effect of self-efficacy on stress-coping methods of health related and non-health related department college students. Method: A questionnaire survey was conducted on 533 students (268 health department and 265 non-health department) of health department and non-health department students at 1 university and 2 university in Gyeonggi-do, jeollabuk-do and jeollanam-do. Results: The results were statistically analyzed using SPSS 12.0, which made no statistically-significant difference among health and non-health students. The study on the effect of self-efficacy on stress-coping methods has revealed that both health and non-health department students showed statistically-significant positive correlation between self-efficacy and emotion-centered coping methods. Also, Social efficacy had negative correlation with social-supported coping methods. While non-health department students had statistically-significant positive correlation between self-efficacy and wishful coping. Conclusion: Accordingly, it has been revealed that self-efficacy is effective in stress-coping methods.