This paper is to investigate the effects of the asymmetrical support stiffness on the stability of a supercritical driveshaft with asymmetrical shaft stiffness and anisotropic bearings. The equations of motion is derived for a system including a rigid disk, a massless flexible asymmetric shaft, anisotropic bearings and a support beam. The Floquet theory is applied to perform the stability analysis with the variation of the support stiffness, the shaft asymmetry, the shaft damping and the shaft speed. The results show that the asymmetric support stiffness is closely related to the stability caused by primary resonance as well as the supercritical operation. First, the stiffness variation can stabilize the system around primary resonance by weakening the parametric resonance from the shaft asymmetry. Second, it also improve the stability characteristics at a supercritical operation when the support stiffness is not so high relative to the shaft stiffness.