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Small Diameter Double Layer Tubular Scaffolds Using Highly Elastic PLCL Copolymer for Vascular Tissue Engineering
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  • Small Diameter Double Layer Tubular Scaffolds Using Highly Elastic PLCL Copolymer for Vascular Tissue Engineering
  • Small Diameter Double Layer Tubular Scaffolds Using Highly Elastic PLCL Copolymer for Vascular Tissue Engineering
저자명
Hassan. Kavitha,Kim. Sang-Hoon,Park. In-Su,Lee. Sun-Hee,Kim. Su-Hee,Jung. Young-Mee,Kim. Sang-Heon,Kim. Soo-Hyun
간행물명
Macromolecular research
권/호정보
2011년|19권 2호|pp.122-129 (8 pages)
발행정보
한국고분자학회
파일정보
정기간행물|ENG|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Tubular double layered scaffolds were fabricated using a biodegradable and elastic polymer, poly(L-lactide-co-${varepsilon}$-caprolactone) (PLCL, 50:50), which was comprised of an outer fibrous gel spun layer and inner porous dip coated layer. The mechanical properties were evaluated and compared with a rabbit aorta and expanded poly-tetrafluoroethylene (ePTFE). The PLCL scaffolds had circumferentially stronger tensile stress than the rabbit aorta and ePTFE graft, and its longitudinal stress was similar to a rabbit aorta but weaker than ePTFE. The E-modulus of the PLCL scaffold was significantly lower than that of ePTFE but significantly higher than that of the native rabbit aorta, this result was reversible in the case of compliance. There was no significant difference in suture retention strength and burst pressure compared to ePTFE grafts. The scaffolds were seeded with SMCs and cultured under dynamic conditions for 13 days to evaluate the cellularity. After a 13 day dynamic culture, the scaffolds showed efficient cell proliferation. Overall, the double layer small diameter PLCL scaffolds exhibited favorable mechanical strength even at a high pressure and good cellularity under dynamic conditions.