Purpose: In this paper, the reliability and reproductivity of anti-reflection (AR) coating on ophthalmic lens using optical monitoring system (OMS) were investigated. Methods: The random error simulation and RunSheet performance in Essential Macleod software to confirm possibility of AR coating using OMS were performed. The coating process of 19 batches was carried out in order to perform reproductivity test of AR coating after simulation process. Results: As a result, the coating results of 19 batches had shown the excellent reproductivity of about 0.5% error. Conclusions: We confirmed the excellent reproductivity and reliability of AR coating on ophthalmic lens using optical monitoring system from our results.