This paper presents a nonlinear soil-structure interaction analysis approach, which can consider precisely characteristics of structures, complicated soil profiles and nonlinear characteristics of soil. Although many methods have been developed to deal with the soil-structure interaction effects in past years, most of them are nearly unpractical since it is difficult to model complicated characteristics of structure and soil precisely. The presented approach overcomes the difficulties by adopting an maligned mesh generation approach and multi-linear model. The applicability of the proposed approach is validated and the effects of complicated characteristics of structure and soil on soil-structure interaction are investigated through the numerical example by the proposed nonlinear soil-structure interaction analysis approach.