Seismic response control method of the bridge structures with semi-active control device, i.e., magneto-rheological (MR) damper, is studied in this paper. Design of various kinds of clipped optimal controller and fuzzy controller are suggested as a semi-active control algorithm. For determining the control force of MR damper, clipped optimal control method adopts bi-state approach, but the fuzzy control method continuously quantifies input currents through fuzzy inference mechanism to finely modulate the damper force. To investigate the performances of the suggested control techniques, numerical simulations of a multi-span continuous bridge system subjected to various earthquakes are performed, and their performances are compared with each other. From the comparison of results, it is shown that the fuzzy control system can provide well-balanced control force between girder and pier in the view point of structural safety and stability and be quite effective in reducing both girder and pier displacements over the existing control method.