3D-QSAR techniques including CoMFA have been used a lot for more than two decades now. For now, the perspective of 3D-QSAR has been changed. The realization of gorge activity cliffs and higher chance correlation with many independent variables (IVs) has changed the requirements. Some suggested the benchmarking datasets for 3D-QSAR. However, were they still useful for right reasons? Here, we propose the requirement of any general purpose 3D-QSAR benchmarking datasets for lead optimization, especially for feasibility test of any IVs. Specifically, we summarize the conceptual requirements for an ideal settings for 3D-QSAR especially CoMFA.