Holographic Data Storage System (HDSS), one of the next generation data storage devices, is a 2-dimensional page oriented memory system using volume hologram. HDSS has many noise sources such as crosstalk, scattering and inter pixel interference, etc. The noise source is changing intensity of the light used for carrying the data signal in HDSS. The inter pixel interference results in decrease of Signal to Noise Ratio and increase of Bit Error Rate. In order to improve these problems, this paper proposes to compensate the inter pixel interference with simple interference mask.