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Snake venom neutralising factor from the root extract of $Emblica$ $officinalis$ $Linn.$
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  • Snake venom neutralising factor from the root extract of $Emblica$ $officinalis$ $Linn.$
저자명
Sarkhel. S.,Chakravarty. A.K.,Das. R.,Gomes. Aparna,Gomes. A.
간행물명
Oriental pharmacy and experimental medicine : OPEM
권/호정보
2011년|11권 1호|pp.25-33 (9 pages)
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The folk use of the Indian medicinal plant Emblica officinalis Linn. root extract and its active compound (Pthalate in nature) against snake venom has been established in experimental animal models. From the root extract of Emblica officinalis, a compound was isolated through silica gel column chromatography and the structure was determined by UV, IR, $^1H$-NMR, $^{13}C$-NMR & EIMS studies. The structure was determined and the active fraction was a pthalate compound, which could neutralize viper and cobra venom induced lethal, hemorrhagic, defibrinogenating, proinflammatory, PLA2, cardiotoxic and neurotoxic activity in experimental animal models. Viper venom induced myotoxicity was antagonized by the compound as shown by the decreased levels of the myotoxicity marker enzymes CPK & LDH. The proinflammatory action of viper venom neutralized by the active compound, showed the involvement of the proinflammatory markers IL-1, IL-6, TNF-${alpha}$. The present study confirmed the phytomedicinal value of an antisnake venom compound present in the root of $Emblica$ $officinalis$.