As an effort to find a new scaffold for ${alpha}$-glucosidase inhibition, we have prepared total 11 phenylalkylated piperazine derivatives and tested their ${alpha}$-glucosidase inhibitory activities. Compounds 8 ($IC_{50}=2.73{pm}0.075mM$) possessing two 3-methoxyphenethyl group on 1,4-position of piperazine showed comparable potency to acarbose used as reference. But other compounds were inactive to ${alpha}$-glucosidase. The result indicated that proper substituents on the piperazine can engender ${alpha}$-glucosidase inhibitory activities on the piperazine derivatives.