In this paper, Based on Two-dimensional Flow Theory, adopting quasi-orthogonal method and point-by-point integration method to design the impeller of the low specific speed centrifugal pump by code, and using RANS (Reynolds Averaged N-S) Equation with a standard k-${varepsilon}$ two-equation turbulence model and log-law wall function to solve 3D turbulent flow field in the impeller of the low specific speed pump. An analysis of the influences of the blade profile on velocity distributions, pressure distributions and pump performance and the investigation of the flow regulation pattern in the impeller of the centrifugal pump are presented. And the result shows that this method can be used as a new way in low speed centrifugal pump impeller design.