In this paper, a simulation-based method is presented to dispose direction finders in three dimensional space for locating targets using the directional data. A direction finder(DF) is a military weapon that is used to find locations of targets that emit radio frequencies by operating two or more DFs simultaneously. If one or more DFs are operated in the air, the accuracy of location estimation can be enhanced by disposing them in a better configuration. By extending the line method, which is a well-known algorithm for 2-D location estimation, into 3-D space, the problem of 3-D location estimation is defined as an nonlinear programming form and solved analytically. Then the optimal disposition of DFs is considered with the presented method in which methods of simulation and search technique are combined. With the suggested algorithm for 3-D disposition of DFs, regions in which targets exist can be effectively covered so that the operation effect of DF be increased.