The alternative load path method based on a column removal scenario has been commonly used to protect building structures from being progressively collapsed due to probable blast loading. However, the method is not appropriate for predicting the progressive collapse when a column still has load-bearing capacity remained after blast. So, the method must be modified to evaluate the capacity of blast resistance. When we evaluate the blast resistance performance of a column, initial bending moment as well as axial force should be considered. That is because the column in a tall building are subjected to eccentric axial force and the initial stress conditions significantly affect the structural behavior of the columns during blast. In this paper, the blast resistance performance of RC columns was evaluated by using the proposed method. The results showed that the blast resistance performance of RC columns according to the various initial stress conditions could be related to the P-M interaction diagram of the columns.