Subminiature devices such as Lab-on-a-chip and p-TAS(Micro Total Analysis System) have been intensively studied in biotechnology and chemistry, In many cases, a micromixer was widely used to mix different solutions for synthesizing novel materials. However, in microfluidic system, there is generally a laminar flow under very small Reynolds number so it is difficult to mix each solution perfectly. To settle this problem, we propose a new mixing mechanism which generates a horizontal and vertical multi-mixing (HVM) flow for effective mixing within a short mixing section. We evaluated the proposed mechanism using CFD analysis, and the results showed that the HVM mechanism had a relative high-effectiveness comparing to the existing methods.