As the volume visualization has been applied to render medical datasets, there has been a requirement to produce high quality images. Even though nice images can be generated by using previous linear filter, high order filter is required for better images. However, it takes much time for high order resampling, so that, overall rendering time is increased. In this paper, we perform high quality volume visualization using the cardinal interpolation. By enabling the empty space leaping which reduces the number of resampling, we achieve the efficient visualization. In detail, we divide the volume data into small blocks and leap empty blocks by referring the upper and lower bound value for each block. We propose a new method to estimate upper and lower bound value of for each block. As the result, we noticeably accelerated high quality volume visualization.