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황금(黃芩)이 척수압박손상 흰쥐의 운동기능장애에 미치는 영향
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  • 황금(黃芩)이 척수압박손상 흰쥐의 운동기능장애에 미치는 영향
저자명
김은석,김평수,김범회,신정원,김성준,손낙원,Kim. Eun-Seok,Kim. Pyung-Soo,Kim. Bum-Hoi,Shin. Jung-Won,Kim. Seong-Joon,Sohn. Nak-Won
간행물명
大韓鍼灸學會誌= The journal of Korean Acupuncture & Moxibustion Society
권/호정보
2011년|28권 3호|pp.33-42 (10 pages)
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대한침구학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Objectives : This study was performed to evaluate the effects of Scutellariae radix (SR) water extract on locomotor dysfunction induced by spinal cord injury (SCI) in rats. Methods : SCI was induced mechanical contusion following laminectomy of 10 th thoracic vertebra in Sprague-Dawley rats. SR was orally given once a day for 7 days after SCI. Neurological behavior was examined with the Basso-Beattie-Bresnahan locomotor rating scale. Tissue damage and nerve fiber degeneration were examined with cresyl violet and luxol fast blue (LFB) histochemistry. Using immunohistochemistry, cellular damages to neurons and nerve fibers were examined MAP-2. Results : 1. SR significantly ameliorated the locomotor dysfunction of the SCI-induced rats. 2. SR significantly reduced the number of motor neurons in the ventral horn of the SCI-induced rat spinal cord. 3. SR attenuated the reduction of nerve fiber shirnakage and degeneration of the SCI-induced rat spinal cord. 4. SR attenuated the reduction of MAP-2 positive cells in the peri-lesion of the SCI-induced rat spinal cord. Conclusions : These results suggest that SR improves the locomotor dysfunction of SCI by reducing degeneration of nerve fibers and motor neuron shrinkage in the ventral horn.