This study aimed to develop AI- (Artificial Intelligence) based thermal control logics and test their performance for identifying the optimal thermal control method in buildings. For this objective, a conventional Two-Position On/Off logic and two AI-based variable logics, which applied ANN (Artificial Neural Network) and ANFIS (Adaptive Neuro-Fuzzy Inference System), have developed. Performance of each logic was tested in a typical two-story residential building in U.S.A. using the computer simulation incorporating MATLAB and IBPT (International Building Physics Toolbox). In the analysis of the test results, AI-based control logic presented the advanced thermal comfort with stability compared to the conventional logic while they did not show significant energy saving effects. In conclusion, the predictive and adaptive AI-based control logics have a potential to maintain interior air temperature more comfortably, and the findings in this study could be a solid foundation for identifying the optimal thermal control method in buildings.