Purpose: The purpose of this study was to identify the effects of CD-ROM education on anxiety and self-care compliance in patients undergoing spinal surgery. Method: This study used a nonequivalent control time difference design. A sample of 51 participants received both CD-ROM education (n=25) or booklet education (n=26) regarding spinal surgery procedure and postoperative self-care. The data were collected using a self-administered questionnaire containing State-Trait Anxiety Inventory (STAI Form Y-2), Visual analog scale, and self-care compliance. Result: The level of trait anxiety in the experimental group was not significantly different from that in the control group (t=-6.44, p=.523). The level of state anxiety in the experimental group was significantly lower than in that the control group according to time changes (F=4.17, p=.018). State anxiety showed significantly negative correlation to self-care compliance (r=-.30, p=.034). Conclusion: The education program using CD-ROM for spinal surgery patients can be applied to nursing practice for relieving state anxiety and promoting self-care compliance.