In the early phase of vehicle development, CAE is conducted as tool for vehicle performance assessment. To maintain acceptable road noise performance, solution for reduced vehicle sensitivity is required. Chassis interface dynamic stiffness characteristics are key component to isolating vibration and noise of road from the vehicle interior. This research provide how to set up the optimized dynamic characteristics under noise effect through DFSS study. CAE-based DOE is performed to build prediction math model, CMS process involves DOE to achieve very fast run times while giving results very comparable. Minimized 95th percentile of performance distribution is applied to minimize vehicle sensitivity and road noise levels variation during the optimization process. Finally, the results of optimization were reviewed for performance and robustness.