This proposes an online loss minimization algorithm for series PI(SPI) based interior permanent magnet synchronous motor(IPMSM) drive to yield high efficiency and high dynamic performance over wide speed range. The loss minimization algorithm is developed based on the motor model. In order to minimize the controllable electrical losses of the motor and thereby maximize the operating efficiency, the d-axis armature current is controlled optimally according to the operating speed and load conditions. For vector control purpose, a SPI is used as a speed controller which enables the utilization of the reluctance torque to achieve high dynamic performance as well as to operate the motor over a wide speed range. Also, this paper proposes current control of model reference adaptive fuzzy controller(MFC), and estimation of speed using artificial neural network(ANN) controller. The proposed efficiency optimization control, SPI, MFC, ANN in this paper is applied to IPMSM drive system, the validity of this paper is proved by analyzing response characteristics in variety operating conditions.