The effect on active transport of $K^+$ and $Na^+$ of cell membrane model which irradiated by radiation was investigated. The cell membrane model used in this experiment was a $Na^+$ type sulfonated copolymerized membrane of styrene and divinylbenezene. The initial flux of the ion was increased with increase of both $H^+$ ion concentration. In this experiment range(pH $0.5^{-3}$), the initial flux of $K^+$ which was not irradiated by radiation was found to be from $7.9{ imes}10^{-4}$ to $7.49{ imes}10^{-3}mole/cm^2{cdot}h$ and that of Na+ from $10.6{ imes}10^{-4}$ to $7.68{ imes}10^{-3}mole/cm^2{cdot}h$. The initial flux of $K^+$ which was irradiated by radiation was found to be from $35.0{ imes}10^{-4}$ to $42.4{ imes}10^{-3}mole/cm^2{cdot}h$ and that of $Na^+$ from $52.0{ imes}10^{-4}$ to $43.3{ imes}10^{-3}mole/cm^2{cdot}h$. The membrane was selective for $K^+$ and the ratio $K^+/Na^+$ was about 1.10. And the driving force of pH of irradiated membrane was significantly increased about 4-5 times than membrane which was not irradiated. As active transport of $K^+$ and $Na^+$ of cell membrane model were abnormal, cell damages were appeared at cell.