This study presents a structural health monitoring (SHM) method for bolted connections by using multi-channel wireless impedance sensor nodes and multiple PZT-interfaces. To achieve the objective, the following approaches are implemented. Firstly, a PZT-interface is designed to monitor bolt loosening in bolted connection based on variation of electro-mechanical(EM) impedance signatures. Secondly, a wireless impedance sensor node is designed for autonomous, cost-efficient and multi-channel monitoring. For the sensor platform, Imote2 is selected on the basis of its high operating speed, low power requirement and large storage memory. Finally, the performance of the wireless sensor node and the PZT-interfaces is experimentally evaluated for a bolt-connection model Damage monitoring method using root mean square deviation(RMSD) index of EM impedance signatures is utilized to estimate the strength of the bolted joint.