This paper discusses the hypercyclicity of weighted composition operators acting on the space of holomorphic functions on the open unit ball $B_N$ of $mathbb{C}^N$. Several analytic properties of linear fractional self-maps of $B_N$ are given. According to these properties, a few necessary conditions for a weighted composition operator to be hypercyclic in the space of holomorphic functions are proved. Besides, the hypercyclicity of adjoint of weighted composition operators are studied in this paper.