Research information related to application of enzyme as pretreatment and subsequent functional finishing on wool blended textiles for imparting multi-functional properties is still scanty. Yarn-blended wool/cotton fabric was pretreated with both a cellulase (Bactosol-CA) or a protease (Savinase-16.0LEx) in individual, subsequently finished with Synthappret-BAP and ${eta}$-cyclodextrin based combination to impart anti-shrink, anti-microbial, softening and anti-crease properties. The performance of the finished fabrics depended on type of finishing combinations applied rather than enzyme pretreatment. Savinase pretreatment followed by Synthappret+Ceraperm-MW combination finishing impart both anti-shrink property as well as softening, while Bactosol pretreatment followed by ${eta}$-cyclodextrin and sanitize combination finishing impart antimicrobial activity as well as anti-shrink finish to the wool/cotton blend fabric.