In this paper, a time-delay problem of a tele-operated control system is investigated and compensated by neural network. The smith predictor requires an exact system model to deal with a time-delay in the system. To compensate for modeling errors in the configuration of the Smith predictor, a neural network approach is presented. Based on forming the Smith predictor structure, the radial basis function(RBF) neural network estimator is used. Simulation and experimental studies are conducted to show the functionality of the proposed method.