To analyze the regional impact of air temperature increase and precipitation variation on water resources, the variability of precipitation-effectiveness (P-E) ratio which is estimated using precipitation and air temperature data of 59 weather stations operated by the Korean Meteorological Administration (KMA) during 1973~2009 was analyzed. Also runoff data resulting from the Precipitation-Runoff Modelling System (PRMS) modelling were analyzed during 1966~2007. The overall spatio-temporal variability of P-E ratio and runoff data in South Korea is corresponding to the variability of precipitation amount. However some region shows that the P-E ratio decreases even though the trend of precipitation amount increases which may be caused by the air temperature increase. Runoff trend is similar to that of P-E ratio. Precipitation and P-E ratio have decreased all seasons except summer season and it means the reduction of available water resources during those seasons. These variability should be reflected in the spring, fall, and winter water supply strategy.