Techniques for mismatch loss minimization to increase the PV system efficiency are under development recently. In this paper, a method to make diagnosis of PV module mismatch is presented, which uses a concept of operating point factor. The method is based on the fact that the ratio of the incremental conductance of a PV module to instantaneous conductance is 1 when the module is operating at its maximum power point. The variations of module voltage and current are taking place by the maximum power point tracker in the power conditioning units of PV system. The effectiveness of the method is verified through an application to a real PV system.