In the present paper, the effect or symmetrical and asymmetrical bell-shaped stenoses on wall pressure drop, streamline contour, and rise in wall shear stress for the progression of the disease, atherosclerosis has been investigated numerically. The governing equations have been solved by finite volume method. Both steady and pulsatile flow at inlet is considered in our study. It is revealed from the study that the impact of wall pressure and peak wall shear stress on progression of disease are always high for asymmetrical shaped stenosis for both steady and pulsatile flow. The impact of asymmetrical shape on plaque deposition zone is less, if the aggravation changes the shape of stenosis due to change in stricture length only keeping percentage of restriction same. Whereas, the impact of asymmetrical shape on plaque deposition zone will be high, if shape of stenosis changes by increasing both stricture length and percentage of restriction for both steady and pulsatile flow. Impact of pulsatile nature of flow on the aggravation of disease is higher at some time steps in comparison to steady flow.