Given the huge increase in interest in biotechnology, whose applications are being expanded as a new growth engine, investment and agency participation are also increasing. In 2008, the level of investment by the national R&D programs in future emerging technologies (6T) in the field of biotechnology was as great as that in IT, and six agencies and many relevant research institutes are now carrying out various related projects. This paper intends to review the status of investment in biotechnology by analyzing the portfolio and positioning of the national R&D biotechnology programs, which address global issues such as the quality of life, the aging society, and environment and energy, and to propose a new investment strategy and direction for the efficient implementation of the national R&D programs.