Objectives: To characterize autonomic dysfunction in patients with Cold hypersensitivity, their heart rate variability(HRV) were measured and analyzed with cold hypersensitivity patients, compared with those of normal population. Methods: We studied 56 patients visiting Gangnam Kyung-hee korean hospital from 1st January 2010 to 31th December 2010. Heart rate variability were obtained from 28 female patients who suffer from cold hypersensitivity and 28 healthy female controls in resting state. We studied the difference of Heart rate variability between two groups by Independent T-test using SPSS for windows(version 17.0). Results: Standard deviation of NN interval(SDNN), total power(TP), Very low frequency(VLF) in patients with cold hypersensitivity were significantly different with those of controls. While no significant differences were observed in square root of mean squared differences of successive NN intervals (RMSSD), low frequency (LF) and high frequency(HF). Conclusions: The decreased values of heart rate variability(HRV) study means that they may have some kinds of imbalance in autonomic nervous system in cold hypersensitivity patients. heart rate variabiliry(HRV) study might be a tool of diagnosis and predictors in cold hypersensitivity patients.