Objectives: The purpose of this study is to report the effect of oriental medicine on 2 patients with secondary amenorrhea. Methods: The patients who had secondary amenorrhea were treated by oriental medical treatments such as herbal medication(Gami-joukyung-tang, Gwibi-tanggagam-bang), acupuncture and moxibustion therapy. Results: After oriental medical treatments, the patients could have their periods again and their menstrual condition was improved. Conclusion: This case report shows that the oriental medical therapy is effective for treating secondary amenorrhea.