Abiotic and biotic stress conditions cause extensive losses to maize production, mainly due to protein dysfunction in these condi-tions. In higher plants, the occurrence of heat-shock proteins (HSPs) in response to different environmental stresses is a universal phenomenon and has been well documented. Many studies have demonstrated that most HSPs are involved in many regulatory path-ways, act as molecular chaperones for other cell proteins, and have strong cytoprotective effects. Although many functional roles for HSPs are known, the mechanisms for these multiple functions are not entirely understood. Here we reviewed the correlation among HSP genes/proteins and plant tolerance, especially maize, in different environmental stresses. Due to the low availability of informa-tion regarding the expression of HSP genes in response to different stresses in maize, we decided to mine databases in order to gener-ate ew insights related to this topic.