Objectives : The purpose of this study was to report the clinical effect of herb medicine (Samryungbeakchul-sangami) on chronic renal disease. Methods : 8 patients diagnosed with chronic renal disease were enrolled in this study. They were treated with herb medicine (Samryungbeakchul-san gami) therapy. To evaluate the therapeutic effect, before and after treatment, we measured laboratory examinations: BUN, creatinine, glomerular filtration rate (GFR). Results : After treatment, improvement was seen in symptoms and in BUN, creatinine and GFR. Conclusions : This study suggests that herb medicine (Samryungbeakchul-san gami) is significantly effective in treating chronic renal disease.