This study investigates the efficacy and coping strategies of Home Economics teachers in secondary schools. Data were collected from 75 Home Economics teachers via a mailed survey and from 282 Home Economics teachers via an online survey. Descriptive statistics including frequency, percentage, average, and standard deviation; in addition, the ANOVA, t-test, multiple linear regression, and correlation results were reported using SPSS statistics 17.0. The results were as follows: First, the average Home Economics teachers efficacy level was 3.82 out of 5-point Likert scale. The efficacy level of learning assistance was the highest. The composite efficacy of Home Economics teachers showed a significant difference depending on the major. Second, the averages of the positive and negative coping strategy level of Home Economics teachers were 3.54 and 2.03, respectively. Third, the efficacy of instructional strategy out of the five components of efficacy was the most influential to the positive coping strategy. There was no significant relationship between teacher efficacy and the negative strategy.