In this paper we dene the notions of left *-bimultiplier, *-bimultiplier and generalized *-biderivation, and to prove that if a semiprime *-ring admits a left *-bimultiplier M, then M maps R ${ imes}$ R into Z(R). In Section 3, we discuss the applications of theory of *-bimultipliers. Further, it was shown that if a semiprime *-ring R admits a symmetric generalized *-biderivation G : R ${ imes}$ R ${ ightarrow}$ R with an associated nonzero symmetric *-biderivation R ${ imes}$ R ${ ightarrow}$ R, then G maps R ${ imes}$ R into Z(R). As an application, we establish corresponding results in the setting of $C^*$-algebra.