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Randomized clinical trial on the efficacy of Escherichia coli-derived rhBMP-2 with ${eta}$-TCP/HA in extraction socket
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  • Randomized clinical trial on the efficacy of Escherichia coli-derived rhBMP-2 with ${eta}$-TCP/HA in extraction socket
  • Randomized clinical trial on the efficacy of Escherichia coli-derived rhBMP-2 with ${eta}$-TCP/HA in extraction socket
저자명
Huh. Jung-Bo,Lee. Hyo-Jung,Jang. Ji-Woong,Kim. Myung-Jin,Yun. Pil-Young,Kim. Su-Hong,Choi. Kyung-Hee,Kim. Young-Kyun,Cho. Kyoo-S
간행물명
The journal of advanced prosthodontics
권/호정보
2011년|3권 3호|pp.161-165 (5 pages)
발행정보
대한치과보철학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

PURPOSE. This randomized clinical trial was conducted to assess the safety and effectiveness of the ErhBMP-2 in alveolar bone regeneration as well as preservation of the ${eta}$-TCP bone graft material that contains ErhBMP-2. MATERIALS AND METHODS. This study involved 72 patients at the 3 study centers. The patients, who were divided into 2 groups: the experiment group who had ErhBMP-2 coated TCP/HA and the control group who had TCP/HA graft material alone transplanted immediately after tooth extraction. CT was taken before and 3 months after the transplantation and healing status was compared between the two groups. The efficacy endpoints that were used to measure the degree of bone induction included alveolar bone height and 3 measurements of bone width. The paired t test was used to determine the significance of the changes (P<.05). RESULTS. Changes in alveolar bone height were $-1.087{pm}1.413$ mm in the control group and $-.059{pm}0.960$ mm in the experimental group (P<.01). At 25% extraction socket length [ESL], the changes were $0.006{pm}1.149$ mm in the control group and $1.279{pm}1.387$ mm in the experimental group. At 50% ESL, the changes were $0.542{pm}1.157$ mm and $1.239{pm}1.249$ mm, respectively (P<.01 for 25% ESL, and P<.05 for 50% ESL). During the experiment, no adverse reactions to the graft material were observed. CONCLUSION. ErhBMP-2 coated ${eta}$-TCP/HA were found to be more effective in preserving alveolar bone than conventional ${eta}$-TCP/HA alloplastic bone graft materials.