Since the general quality of life has been improving, people have become interested in "well-being." The widespread acceptance of the importance of "well-being" to quality of life has encouraged people to take more interest in getting health information online when they need it. Expansive use of online health information suggests that individual characteristics (i.e., gender and other traits), Website features, and perceived trust are related to the primary concern for many online health information consumers. This study examines whether familiarity, perceived security, and reputation of health information on various Websites influence the relationship of trust and intention to use by gender. These research results will contribute to the adoption of online health information by gender and, moreover, will provide companies with an understanding of key characteristics of consumers who use emoticons and provide useful implications for marketing strategies to current and future consumers.